Difference between revisions of "General Information/Fuzzy Borders"
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As shown in [[:Image:1.13.1.png|Fig.1.13.1]], examples have now been identified in which passenger genes are located within an IS, called tIS (ISs and relatives with passenger genes)<ref><nowiki><pubmed>19286454</pubmed></nowiki></ref> or in which TE with typical transposon structures are devoid of transposition proteins (MITES and MIC)<ref><nowiki><pubmed>15228527</pubmed></nowiki></ref><ref><nowiki><pubmed>10320586</pubmed></nowiki></ref><ref><nowiki><pubmed>11814653</pubmed></nowiki></ref><ref><nowiki><pubmed>12520302</pubmed></nowiki></ref>. The (hypothetical) relationship between these different autonomous (with transposase) and non-autonomous IS derivatives is indicated in [[:Image:1.13.1.png|Fig.1.13.1]] <ref><nowiki><pubmed>24499397</pubmed></nowiki></ref><ref><nowiki><pubmed>26104715</pubmed></nowiki></ref>. | As shown in [[:Image:1.13.1.png|Fig.1.13.1]], examples have now been identified in which passenger genes are located within an IS, called tIS (ISs and relatives with passenger genes)<ref><nowiki><pubmed>19286454</pubmed></nowiki></ref> or in which TE with typical transposon structures are devoid of transposition proteins (MITES and MIC)<ref><nowiki><pubmed>15228527</pubmed></nowiki></ref><ref><nowiki><pubmed>10320586</pubmed></nowiki></ref><ref><nowiki><pubmed>11814653</pubmed></nowiki></ref><ref><nowiki><pubmed>12520302</pubmed></nowiki></ref>. The (hypothetical) relationship between these different autonomous (with transposase) and non-autonomous IS derivatives is indicated in [[:Image:1.13.1.png|Fig.1.13.1]] <ref><nowiki><pubmed>24499397</pubmed></nowiki></ref><ref><nowiki><pubmed>26104715</pubmed></nowiki></ref>. | ||
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==Bibliography== | ==Bibliography== | ||
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Revision as of 17:42, 30 April 2020
Fuzzy Borders
With our increasing knowledge of the diversity of the mobilome, the distinction between IS and other TE is becoming increasing unclear. The major feature used to distinguish IS from transposons was that the former (Fig.1.13.1) lack phenotypically detectable passenger genes (genes not involved in the transposition process) while the latter include one or more such genes (for antibiotic resistance, virulence and pathogenicity functions or genes permitting the use of unusual compounds). This is no longer the case (Fig.1.13.1).
As shown in Fig.1.13.1, examples have now been identified in which passenger genes are located within an IS, called tIS (ISs and relatives with passenger genes)[1] or in which TE with typical transposon structures are devoid of transposition proteins (MITES and MIC)[2][3][4][5]. The (hypothetical) relationship between these different autonomous (with transposase) and non-autonomous IS derivatives is indicated in Fig.1.13.1 [6][7].
