IS Families/ISAzo13 family
Jump to navigation
Jump to search
This family, represented by 37 members in ISfinder emerged from the ISNCY orphan group. It is based on both Tpase and IR sequence similarities (Fig.ISAzo13). Insertion generates a 3bp AT-rich DR and the ends have a consensus GGa/g. Their Tpases are highly conserved with a probable DDE motif and an HTH motif at the N-terminus which could function as a DNA binding domain. Two members encode two orfs with a possible PRF (Programmed Transcriptional Frameshifting) motif of 8 or 9 A while the other members encode a unique orf which includes a triple lysine at the equivalent position (Gourbeyre, unpublished)[1].
Fig. ISAzo13. General ISAzo13 characteristics, average length and common ends. Top: Distribution of IS length (base pairs) of ISAzo13 family members. The number of examples used in the sample is shown above each column. Bottom: Left (IRL) and right IRR inverted terminal repeats are shown in WebLogo format.
Bibliography
