General Information

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Fig.1.1. The Busy Genome: Elements of Horizontal Exchange. The genome backbone, which includes housekeeping genes, is shown as the inner circle (blue). The "mobilome" is shown in the outer circle. This includes a number of different types of MGE both intercellular (some genomic islands, prophages, and conjugative transposons) and intracellular (Insertion sequences, compound and unit transposons, integrons, and super integrons). An important class of intercellular MGE, the plasmids, act as transposon vectors and facilitate TE movement within the plasmidome.
1. Overview
2. Insertion Sequence History and Early Transposition Models
3. What Is an IS?
4. ISfinder and the Growing Number of IS
5. IS Identification, nomenclature and naming attribution
6. IS Distribution
7. Major Groups are Defined by the Type of Transposase They Use
8. Fuzzy Borders
9. tIS - IS and relatives with passenger genes
10. IS derivatives of Tn3 family transposons
11. IS related to Integrative Conjugative Elements (ICEs)
12. IS91 and ISCR families
13. Non-autonomous IS derivatives
14. Relationship Between IS and Eukaryotic TE
15. Impact of IS on Genome Evolution - The Importance of Time Scale
16. Target Choice
17. Influence of transposition mechanisms on genome impact
18. IS and Gene Expression
19. IS Organization
20. Control of transposition activity
21. Transposase expression and activity
22. Reaction mechanisms
23. The Casposases