Difference between revisions of "IS Families/ISAzo13 family"

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[[Image:ISAzo13.1.png|thumb|center|500x500px|'''Fig. ISAzo13.'''|alt=]]
[[Image:ISAzo13.1.png|thumb|center|500x500px|'''Fig. ISAzo13.'''|alt=]]
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Revision as of 17:39, 1 June 2020

This family, represented by 37 members in ISfinder emerged from the ISNCY orphan group. It is based on both Tpase and IR sequence similarities (Fig.ISAzo13). Insertion generates a 3bp AT-rich DR and the ends have a consensus GGa/g. Their Tpases are highly conserved with a probable DDE motif and an HTH motif at the N-terminus which could function as a DNA binding domain. Two members encode two orfs with a possible PRF (programmed transcriptional frameshifting) motif of 8 or 9 A while the other members encode a unique orf which includes a triple lysine at the equivalent position (Gourbeyre, unpublished).

Fig. ISAzo13.