Difference between revisions of "General Information/Overview"

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[[Image:fig1.png|thumb|500x500px|'''Fig.1.1.1.''' The Busy Genome: Elements of Horizontal Exchange. The genome backbone, which includes housekeeping genes, is shown as the inner circle (blue). The "mobilome" is shown in the outer circle. This includes a number of different types of MGE both intercellular (some genomic islands, prophages and conjugative transposons) and intracellular (Insertion sequences, compound and unit transposons, integrons and super integrons). Not shown are an important class of intercellular MGE, the plasmids.The insert indicates the length of non-backbone DNA (mostly mobilome components) in some closely related Enterobacteria. |alt=|border]]   
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'''<big>T</big>'''he idea that many prokaryotic genomes are mosaic, composed of a "central genome backbone" of essential and house-keeping genes (the core genome) interspersed with DNA segments constituting the "mobilome" (a variety of accessory genes that form part of the pan-genome)[[:Image:fig1.png|(Fig.1.1)]], is now common currency <ref name=":0"><pubmed>16185861</pubmed></ref><ref name=":1"><pubmed>19086349</pubmed></ref>.
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'''<big>T</big>'''he idea that many prokaryotic genomes are mosaic, composed of a "central genome backbone" of essential and house-keeping genes (the core genome) interspersed with DNA segments constituting the "mobilome" (a variety of accessory genes that form part of the pan-genome)[[:Image:fig1.png|(Fig.1.1.1)]], is now common currency <ref name=":0"><pubmed>16185861</pubmed></nowiki></ref><ref name=":1"><pubmed>19086349</pubmed></nowiki></ref>.  
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The mobilome embraces several types of genetic units which, as their collective name indicates, can move from place to place in a particular genome or from cell to cell. These [[wikipedia:Mobile_genetic_elements|'''M'''obile '''G'''enetic '''E'''lements]] (MGE) can be divided into two major groups: those, such as [[wikipedia:Plasmid|plasmids]] and [[wikipedia:Bacteriophage|bacteriophages]], that are transmissible from cell to cell (the intercellular MGE), and those that cannot themselves undergo transfer but which are transferred following integration into members of the first group (the intracellular MGE).
  
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The mobilome embraces several types of genetic units which, as their collective name indicates, can move from place to place in a particular genome or from cell to cell. These mobile genetic elements (MGE) can be divided into two major groups: those, such as plasmids and bacteriophages, that are transmissible from cell to cell (the intercellular MGE), and those that cannot themselves undergo transfer but which are transferred following integration into members of the first group (the intracellular MGE).  
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Intracellular MGE or [[wikipedia:Transposable_element|'''T'''ransposable '''E'''lements]] (TE) include transposons (Tn) and '''I'''nsertion '''S'''equences (IS) but can embrace [[wikipedia:Integron|integrons]] (In) <ref name=":2"><pubmed>26104695</pubmed></ref><ref name=":3"><pubmed>26961432</pubmed></ref> and [[wikipedia:Intron|introns]] <ref>Craig NL, Chandler M, Gellert M, Lambowitz A, Rice PA, Sandmeyer S. Mobile DNA III. 3rd ed. Washington, DC: ASM; 2015. </ref><ref name=":4"><pubmed>26104554</pubmed></ref><ref name=":5"><pubmed>25960782</pubmed></ref><ref name=":6"><pubmed>26104699</pubmed></ref>.
  
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Intracellular MGE or transposable elements (TE) include transposons (Tn) and insertion sequences (IS) but can embrace integrons (In) <ref name=":2"><pubmed>26104695</pubmed></nowiki></ref><ref name=":3"><pubmed>26961432</pubmed></nowiki></ref> and introns <ref name=":4"><pubmed>26104554</pubmed></nowiki></ref><ref name=":5"><pubmed>25960782</pubmed></nowiki></ref><ref name=":6"><pubmed>26104699</pubmed></nowiki></ref>.
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Originally Tn were distinguished from IS since they carry passenger (also called cargo) genes not involved in catalyzing or regulating TE movement. Most eukaryotic DNA transposons have relatives among the prokaryotic IS (see <ref name=":7"><pubmed>20067338</pubmed></ref>) and it is not surprising that a variety of these elements carrying passenger genes are now also being identified <ref name=":8"><pubmed>19174482</pubmed></ref><ref name=":9"><pubmed>23548000</pubmed></ref>.  
  
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Originally Tn were distinguished from IS since they carry passenger (also called cargo) genes not involved in catalyzing or regulating TE movement. Most eukaryotic DNA transposons have relatives among the prokaryotic IS (see <ref name=":7"><pubmed>20067338</pubmed></nowiki></ref>) and it is not surprising that a variety of these elements carrying passenger genes are now also being identified <ref name=":8"><pubmed>19174482</pubmed></nowiki></ref><ref name=":9"><pubmed>23548000</pubmed></nowiki></ref>.   
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Prokaryotes harbor a host of such elements as well as several types of structure possessing characteristics of both groups (e.g. [[wikipedia:Mobile_genetic_elements|'''I'''ntegrative '''C'''onjugative '''E'''lements]] (ICE), originally called conjugative transposons, as well as other types of non-conjunctive [[wikipedia:Genomic_island|genomic islands]]) <ref name=":10"><pubmed>15207870</pubmed></ref><ref name=":11"><pubmed>15100694</pubmed></ref><ref name=":12"><pubmed>23435978</pubmed></ref>.[[Image:fig1.png|thumb|600x600px|'''Fig.1.1.''' The Busy Genome: Elements of Horizontal Exchange. The genome backbone, which includes housekeeping genes, is shown as the inner circle (blue). The "mobilome" is shown in the outer circle. This includes a number of different types of MGE both intercellular (some genomic islands, prophages, and conjugative transposons) and intracellular (Insertion sequences, compound and unit transposons, integrons, and super integrons). An important class of intercellular MGE, the plasmids, act as transposon vectors and facilitate TE movement within the plasmidome.  |alt=|border|center]]
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Prokaryotes harbor a host of such elements as well as several types of structure possessing characteristics of both groups (e.g. Integrative Conjugative Elements, ICE, originally called conjugative transposons, as well as other types of non-conjunctive genomic islands) <ref name=":10"><pubmed>15207870</pubmed></nowiki></ref><ref name=":11"><pubmed>15100694</pubmed></nowiki></ref><ref name=":12"><pubmed>23435978</pubmed></nowiki></ref>.
 
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==Bibliography==
 
==Bibliography==
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Latest revision as of 12:18, 5 December 2022

The idea that many prokaryotic genomes are mosaic, composed of a "central genome backbone" of essential and house-keeping genes (the core genome) interspersed with DNA segments constituting the "mobilome" (a variety of accessory genes that form part of the pan-genome)(Fig.1.1), is now common currency [1][2]. The mobilome embraces several types of genetic units which, as their collective name indicates, can move from place to place in a particular genome or from cell to cell. These Mobile Genetic Elements (MGE) can be divided into two major groups: those, such as plasmids and bacteriophages, that are transmissible from cell to cell (the intercellular MGE), and those that cannot themselves undergo transfer but which are transferred following integration into members of the first group (the intracellular MGE).

Intracellular MGE or Transposable Elements (TE) include transposons (Tn) and Insertion Sequences (IS) but can embrace integrons (In) [3][4] and introns [5][6][7][8].

Originally Tn were distinguished from IS since they carry passenger (also called cargo) genes not involved in catalyzing or regulating TE movement. Most eukaryotic DNA transposons have relatives among the prokaryotic IS (see [9]) and it is not surprising that a variety of these elements carrying passenger genes are now also being identified [10][11].

Prokaryotes harbor a host of such elements as well as several types of structure possessing characteristics of both groups (e.g. Integrative Conjugative Elements (ICE), originally called conjugative transposons, as well as other types of non-conjunctive genomic islands) [12][13][14].

Fig.1.1. The Busy Genome: Elements of Horizontal Exchange. The genome backbone, which includes housekeeping genes, is shown as the inner circle (blue). The "mobilome" is shown in the outer circle. This includes a number of different types of MGE both intercellular (some genomic islands, prophages, and conjugative transposons) and intracellular (Insertion sequences, compound and unit transposons, integrons, and super integrons). An important class of intercellular MGE, the plasmids, act as transposon vectors and facilitate TE movement within the plasmidome.

Bibliography

  1. ↑ Medini D, Donati C, Tettelin H, Masignani V, Rappuoli R . The microbial pan-genome. - Curr Opin Genet Dev: 2005 Dec, 15(6);589-94 [PubMed:16185861] [DOI]
  2. ↑ Tettelin H, Riley D, Cattuto C, Medini D . Comparative genomics: the bacterial pan-genome. - Curr Opin Microbiol: 2008 Oct, 11(5);472-7 [PubMed:19086349] [DOI]
  3. ↑
  4. ↑
  5. ↑ Craig NL, Chandler M, Gellert M, Lambowitz A, Rice PA, Sandmeyer S. Mobile DNA III. 3rd ed. Washington, DC: ASM; 2015.
  6. ↑ Lambowitz AM, Belfort M . Mobile Bacterial Group II Introns at the Crux of Eukaryotic Evolution. - Microbiol Spectr: 2015 Feb, 3(1);MDNA3-0050-2014 [PubMed:26104554] [DOI]
  7. ↑
  8. ↑
  9. ↑
  10. ↑ Bao W, Jurka MG, Kapitonov VV, Jurka J . New superfamilies of eukaryotic DNA transposons and their internal divisions. - Mol Biol Evol: 2009 May, 26(5);983-93 [PubMed:19174482] [DOI]
  11. ↑
  12. ↑ Burrus V, Waldor MK . Shaping bacterial genomes with integrative and conjugative elements. - Res Microbiol: 2004 Jun, 155(5);376-86 [PubMed:15207870] [DOI]
  13. ↑
  14. ↑ Guérillot R, Da Cunha V, Sauvage E, Bouchier C, Glaser P . Modular evolution of TnGBSs, a new family of integrative and conjugative elements associating insertion sequence transposition, plasmid replication, and conjugation for their spreading. - J Bacteriol: 2013 May, 195(9);1979-90 [PubMed:23435978] [DOI]


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